Summary Notes:
The circadian rhythm controls what happens when
Via genes, the circadian rhythm controls the creation of sperm, eggs, sex hormones, puberty and overall fertility1
Mitochondrial health depends on a healthy circadian rhythm to balance pro-oxidative and antioxidant forces (redox) in pregnancy2
Redox balance allows sperm creation, egg creation, and implantation to complete3
Melatonin, controlled by the circadian rhythm, plays a major role in balancing redox as well as fertility4
Any free person can access a lifestyle that nurtures their circadian rhythm
The placenta connects the baby to its mother’s circadian rhythm in utero5
Placental health requires high melatonin6
Melatonin itself is a powerful endogenous—ie, made by the body—antioxidant that protects health of both mother and baby in pregnancy7
Melatonin climbs throughout pregnancy and peaks at the time of birth8
There is a synergy between melatonin and oxytocin in the uterus9
Oxytocin vs pitocin
Endogenous melatonin vs synthetic melatonin
Natural boost of melatonin: tryptophan-rich food —> sunshine —> darkness
Over the counter melatonin is unreliable because the dose is highly variable despite what label says10
Real life “Easter egg”: I recorded this workshop from my gazebo and at this point in the recording my chickens 🐔and rooster 🐓 swarmed me… I later found out a bear was stalking them! 🐻 rawr!
It takes about 20 years for new research to get into clinical guidelines
Light is the most important factor in regulating the circadian rhythm
Lifelong health conditions are related to the circadian programming received in the early life beginning in the womb11
Sleep quality, another effect of the circadian rhythm, is correlated with all forms of mental health across the lifespan12
Circadian systems have multiple modes per day (ie, sleep/wake)
A zeitgeber is a “time-giver” that directly affects the circadian rhythm13
There are primary (also called “self-sufficient”) and secondary zeitgebers
Primary zeitgebers—for humans, that’s light/temperature and meal timing—directly affect the biological circadian clocks
Secondary zeitgebers (ie, social cues) support or detract from the effects of the primary zeitgebers
Questions about anything in this video? Drop in the comments or send me a DM:
Sciarra, F., Franceschini, E., Campolo, F., Gianfrilli, D., Pallotti, F., Paoli, D., Isidori, A. M., & Venneri, M. A. (2020). Disruption of Circadian Rhythms: A Crucial Factor in the Etiology of Infertility. International journal of molecular sciences, 21(11), 3943. https://doi.org/10.3390/ijms21113943
Toboła-Wróbel, K., Pietryga, M., Dydowicz, P., Napierała, M., Brązert, J., & Florek, E. (2020). Association of Oxidative Stress on Pregnancy. Oxidative medicine and cellular longevity, 2020, 6398520. https://doi.org/10.1155/2020/6398520
Almansa-Ordonez, A., Bellido, R., Vassena, R., Barragan, M., & Zambelli, F. (2020). Oxidative Stress in Reproduction: A Mitochondrial Perspective. Biology, 9(9), 269. https://doi.org/10.3390/biology9090269
Yong, W., Ma, H., Na, M., Gao, T., Zhang, Y., Hao, L., Yu, H., Yang, H., & Deng, X. (2021). Roles of melatonin in the field of reproductive medicine. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 144, 112001. https://doi.org/10.1016/j.biopha.2021.112001
Wong, S. D., Wright, K. P., Jr, Spencer, R. L., Vetter, C., Hicks, L. M., Jenni, O. G., & LeBourgeois, M. K. (2022). Development of the circadian system in early life: maternal and environmental factors. Journal of physiological anthropology, 41(1), 22. https://doi.org/10.1186/s40101-022-00294-0
Chuffa, L. G. A., Lupi, L. A., Cucielo, M. S., Silveira, H. S., Reiter, R. J., & Seiva, F. R. F. (2019). Melatonin Promotes Uterine and Placental Health: Potential Molecular Mechanisms. International journal of molecular sciences, 21(1), 300. https://doi.org/10.3390/ijms21010300
Langston-Cox, A., Marshall, S. A., Lu, D., Palmer, K. R., & Wallace, E. M. (2021). Melatonin for the Management of Preeclampsia: A Review. Antioxidants (Basel, Switzerland), 10(3), 376. https://doi.org/10.3390/antiox10030376
Reiter, R. J., Tan, D. X., Korkmaz, A., & Rosales-Corral, S. A. (2014). Melatonin and stable circadian rhythms optimize maternal, placental and fetal physiology. Human reproduction update, 20(2), 293–307. https://doi.org/10.1093/humupd/dmt054
Olcese, J., & Beesley, S. (2014). Clinical significance of melatonin receptors in the human myometrium. Fertility and sterility, 102(2), 329–335. https://doi.org/10.1016/j.fertnstert.2014.06.020
Erland, L. A., & Saxena, P. K. (2017). Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 13(2), 275–281. https://doi.org/10.5664/jcsm.6462
Hsu, C. N., & Tain, Y. L. (2020). Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease. International journal of molecular sciences, 21(6), 2232. https://doi.org/10.3390/ijms21062232
Alachkar, A., Lee, J., Asthana, K., Vakil Monfared, R., Chen, J., Alhassen, S., Samad, M., Wood, M., Mayer, E. A., & Baldi, P. (2022). The hidden link between circadian entropy and mental health disorders. Translational psychiatry, 12(1), 281. https://doi.org/10.1038/s41398-022-02028-3
Roenneberg, T., & Merrow, M. (2007). Entrainment of the human circadian clock. Cold Spring Harbor symposia on quantitative biology, 72, 293–299. https://doi.org/10.1101/sqb.2007.72.043
PART 1: CIRCADIAN HEALTH IN PREGNANCY