Experimental Evidence is Still Lacking🔬

⭐️ Opinion: that's good thing.

Oct 23, 2021

∙ Paid

Hi,

There's a thread in research about circadian disruption that presents an interesting dilemma. To illustrate, I'm going to use a recent review about circadian dysfunction in autism spectrum disorders (ASDs)1. Here are some direct quotes from just the first two pages that exemplify the issue:

...the dysfunction of the circadian timing system may be associated with ASD and its pathogenesis...
...circadian dysfunctions have been linked to an increasing number of human diseases including metabolic syndromes, cardiovascular diseases, diabetes, and cancer...
...anomalies in timing have been observed in neurological and psychiatric diseases including seasonal affective disorders, bipolar disorder, and schizophrenia,...
...the disruption of daily activity rhythms is often associated with or even precedes underlying pathophysiological changes in the brain...

I see this kind of passive and hedging language all over in circadian lit. Here's the punchline from this paper’s conclusion:

...experimental …

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