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Lesson 03: Circadian disruption and reproductive dysfunction in women

Lesson 03 in The Circadian and Quantum Childbearing Year all about how circadian disruption upsets health and interferes with the female reproductive system

This video lesson shares the most common co-morbidities that interfere with reproductive health. It also shares some of the things I have learned about what makes this information resonant and actionable while working with clients and teaching this information.

It is the 3rd lesson in The Circadian and Quantum Childbearing Year, my new coaching program, which is now located INSIDE the Practitioner tier of Brighter Days, Darker Nights. To learn more about how this new community learning program can support you in learning and teaching this information, visit:

The first two lessons covered circadian health, and how healthy circadian rhythms support reproductive function in women and men.

Today’s lesson starts unpacking the question of how disruption of the circadian rhythm negatively affects health and reproductive function.

Below, find starting points for your optional extended learning activities. Dive into one or more of the listed co-morbidities (these are all commonly diagnosed with female infertility and adverse pregnancy outcomes). See what you can find about how these chronic health conditions are affected by circadian disruption.

Recommended reading options and topics for homework:

First, here are a couple of posts from the archive to support this lesson:

And below are starting points for your research.

Circadian disruption and the myriad co-morbidities that affect reproductive potential:

The papers below address autoimmune disorders, infectious diseases, cancer, gastrointestinal disorders, heart and circulatory disorders, HIV and AIDS, kidney disease, mental health disorders, metabolic disorders, glandular disorders, muscular and connective tissue disorders, respiratory disorders, skeletal and joint disorders, skin disorders, and white blood cell/other immunological disorders. All of these are often diagnosed alongside reproductive difficulty, and all have a relationship with the circadian rhythm.

Autoimmune disorders

Awuah, W. A., Huang, H., Kalmanovich, J., Mehta, A., Mikhailova, T., Ng, J. C., Abdul-Rahman, T., Adebusoye, F. T., Tan, J. K., Kamanousa, K., Ferreira, T., Roy, S., Kundu, M., Yarlagadda, R., Mukerjee, N., Alexiou, A., & Papadakis, M. (2023). Circadian rhythm in systemic autoimmune conditions: Potential of chrono-immunology in clinical practice: A narrative review. Medicine, 102(32), e34614.

Infectious diseases

Rijo-Ferreira, F., & Takahashi, J. S. (2022). Circadian rhythms in infectious diseases and symbiosis. Seminars in cell & developmental biology, 126, 37–44.


Jagielo, A. D., Benedict, C., & Spiegel, D. (2023). Circadian, hormonal, and sleep rhythms: effects on cancer progression implications for treatment. Frontiers in oncology, 13, 1269378.

Gastrointestinal disorders

Voigt, R. M., Forsyth, C. B., & Keshavarzian, A. (2019). Circadian rhythms: a regulator of gastrointestinal health and dysfunction. Expert review of gastroenterology & hepatology, 13(5), 411–424.

Heart and circulatory disorders

Chellappa, S. L., Vujovic, N., Williams, J. S., & Scheer, F. A. J. L. (2019). Impact of Circadian Disruption on Cardiovascular Function and Disease. Trends in endocrinology and metabolism: TEM, 30(10), 767–779.


Shafaati, M., Sadeghniiat, K., Priyanka, Najafia, A., Zandi, M., Akbarpour, S., & Choudhary, O. P. (2023). The relevance of the circadian timing system role in patients with HIV/AIDS: a quick glance. International journal of surgery (London, England), 109(9), 2831–2834.

Kidney disease

Costello, H. M., Johnston, J. G., Juffre, A., Crislip, G. R., & Gumz, M. L. (2022). Circadian clocks of the kidney: function, mechanism, and regulation. Physiological reviews, 102(4), 1669–1701.

Mental health disorders

Codoñer-Franch, P., Gombert, M., Martínez-Raga, J., & Cenit, M. C. (2023). Circadian Disruption and Mental Health: The Chronotherapeutic Potential of Microbiome-Based and Dietary Strategies. International journal of molecular sciences, 24(8), 7579.

Metabolic disorders

Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El-Osta, A., Einat, H., & Kronfeld-Schor, N. (2019). The Circadian Syndrome: is the Metabolic Syndrome and much more!. Journal of internal medicine, 286(2), 181–191.

Glandular disorders


Minnetti, M., Hasenmajer, V., Pofi, R., Venneri, M. A., Alexandraki, K. I., & Isidori, A. M. (2020). Fixing the broken clock in adrenal disorders: focus on glucocorticoids and chronotherapy. The Journal of endocrinology, 246(2), R13–R31.


Ikegami, K., Refetoff, S., Van Cauter, E., & Yoshimura, T. (2019). Interconnection between circadian clocks and thyroid function. Nature reviews. Endocrinology, 15(10), 590–600.


Lin, X. W., Blum, I. D., & Storch, K. F. (2015). Clocks within the Master Gland: Hypophyseal Rhythms and Their Physiological Significance. Journal of biological rhythms, 30(4), 263–276.

Muscular and connective tissue disorders

Aoyama, S., & Shibata, S. (2017). The Role of Circadian Rhythms in Muscular and Osseous Physiology and Their Regulation by Nutrition and Exercise. Frontiers in neuroscience, 11, 63.

Disorders related to the nervous system

Logan, R. W., & McClung, C. A. (2019). Rhythms of life: circadian disruption and brain disorders across the lifespan. Nature reviews. Neuroscience, 20(1), 49–65.

Reproductive organ disorders

Sati L. (2020). Chronodisruption: effects on reproduction, transgenerational health of offspring and epigenome. Reproduction (Cambridge, England), 160(5), R79–R94.

Respiratory disorders

Giri, A., Wang, Q., Rahman, I., & Sundar, I. K. (2022). Circadian molecular clock disruption in chronic pulmonary diseases. Trends in molecular medicine, 28(6), 513–527.

Skeletal and joint disorders

Juliana, N., Azmi, L., Effendy, N. M., Mohd Fahmi Teng, N. I., Abu, I. F., Abu Bakar, N. N., Azmani, S., Yazit, N. A. A., Kadiman, S., & Das, S. (2023). Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies. Nutrients, 15(3), 734.

Skin disorders

Duan, J., Greenberg, E. N., Karri, S. S., & Andersen, B. (2021). The circadian clock and diseases of the skin. FEBS letters, 595(19), 2413–2436.

White blood cell disorders

Jerigova, V., Zeman, M., & Okuliarova, M. (2022). Circadian Disruption and Consequences on Innate Immunity and Inflammatory Response. International journal of molecular sciences, 23(22), 13722.

Homework and extended learning activities:

These topics are just a launching point for the learning journey we are taking in this Circadian and Quantum Birth Community.

Right now, we are in the section dedicated to circadian rhythmicity.

Next, we will lay the foundation for understanding how quantum biology also regulates to these systems.

Then we will put it all together and look in detail at each step of the childbearing process:

  • circadian and quantum preconception through pregnancy, birth, postpartum

  • raising circadian and quantum healthy children through puberty and the realization of their own reproductive potential

Find the upcoming year’s schedule here.

Get feedback on your learning processes by completing the optional assignments below:

This post is for subscribers in the Practitioner plan

A private space for practitioners (and high-achieving parents) to learn and teach circadian and quantum biology in the childbearing year.